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  • Nature Reviews Drug Discovery, Published online: 19 May 2026; doi:10.1038/s41573-026-01442-2Agonistic antibodies initiate signalling by the receptors they target, mimicking the activities of native ligands. This Review discusses the clinical successes and failures of agonistic antibodies and explains how recent mechanistic insights should broaden the scope and improve the safety and efficacy of immunotherapies based on […]
  • Nature Reviews Drug Discovery, Published online: 18 May 2026; doi:10.1038/s41573-026-01449-9Autophagy has a highly complex and context-dependent role in cancer, challenging the development of autophagy-modulating strategies. This Review discusses the potential of targeting autophagy to counteract malignant transformation, prevent disease progression and enable anticancer immunosurveillance. Existing and emerging pharmacological strategies and the associated limitations are critically […]
  • Nature Reviews Drug Discovery, Published online: 13 May 2026; doi:10.1038/d41573-026-00081-xTrends in the landscape of clinical trials of innovative drugs in China since 2015
  • Nature Reviews Drug Discovery, Published online: 13 May 2026; doi:10.1038/s41573-026-01427-1Incretin-based therapies are transforming the treatment of obesity and related comorbidities. This Review outlines the current landscape of obesity drug development, focusing on glucagon-like peptide 1 receptor agonists, multi-receptor agonists, amylin receptor agonists and next-generation oral therapies. Key translational and biological challenges, as well as emerging […]
  • Nature Reviews Drug Discovery, Published online: 12 May 2026; doi:10.1038/d41573-026-00080-yA peptide-guided strategy for kinase activation
  • Nature Reviews Drug Discovery, Published online: 11 May 2026; doi:10.1038/d41573-026-00079-5Eli Lilly inks dual-payload ADCs deal