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  • Nature Reviews Drug Discovery, Published online: 04 October 2024; doi:10.1038/s41573-024-01042-yFollowing the success of the COVID-19 vaccines, mRNA vaccines have now entered development for a wide range of infectious diseases. This Review discusses mRNA vaccine design considerations, delivery strategies and mechanisms of action, assessing mRNA vaccines currently in development for various viruses, bacteria and parasites. The […]
  • Nature Reviews Drug Discovery, Published online: 03 October 2024; doi:10.1038/d41573-024-00165-6A viral–lipid hybrid delivery system for genetic therapies
  • Nature Reviews Drug Discovery, Published online: 02 October 2024; doi:10.1038/d41573-024-00153-wTwo decades of new drug approvals in Japan
  • Nature Reviews Drug Discovery, Published online: 01 October 2024; doi:10.1038/d41573-024-00164-7FDA approves first monoclonal antibody for COPD
  • Nature Reviews Drug Discovery, Published online: 30 September 2024; doi:10.1038/s41573-024-01033-zWith ageing global populations, cellular senescence is gaining increasing attention as a therapeutic target. In their Review, Orr and colleagues discuss ongoing research into senescence in the central nervous system, including promising targets and drugs in development that aim to clear senescent cells or modulate their […]
  • Nature Reviews Drug Discovery, Published online: 27 September 2024; doi:10.1038/d41573-024-00162-9FDA approves first two drugs for rare Niemann–Pick disease