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  • Nature Reviews Drug Discovery, Published online: 26 August 2026; doi:10.1038/d41573-026-00139-wSmall molecule boosts Parkinson disease treatment
  • Nature Reviews Drug Discovery, Published online: 24 August 2026; doi:10.1038/s41573-026-01517-0Transcriptional CDKs coordinate gene expression throughout the transcription cycle and are increasingly recognized as therapeutic targets. This Review examines their roles in cancer-associated transcriptional dysregulation and highlights emerging strategies to modulate transcriptional CDKs for therapeutic benefit.
  • Nature Reviews Drug Discovery, Published online: 24 August 2026; doi:10.1038/s41573-026-01509-0Drug discovery for psychiatric disorders is a slow and challenging process, driven in part by reliance on symptom-based diagnostic criteria that fail to capture the underlying disease biology. In their Perspective, Etkin and co-authors suggest a framework for a precision psychiatry approach, drawing on examples from […]
  • Nature Reviews Drug Discovery, Published online: 12 August 2026; doi:10.1038/d41573-026-00136-zOncolytic virus nabs FDA approval
  • Nature Reviews Drug Discovery, Published online: 10 August 2026; doi:10.1038/d41573-026-00135-0As Takeda’s oveporexton (Orzeyful) becomes a first-in-class treatment for narcolepsy type 1, industry eyes broader indications for orexin receptor agonists.
  • Nature Reviews Drug Discovery, Published online: 07 August 2026; doi:10.1038/s41573-026-01496-2Applications of artificial intelligence (AI) in drug discovery have attracted high interest in recent years, but evidence for clinically relevant impact so far is limited. This Perspective discusses potential reasons, including an insufficient focus on clinical translation during model development and difficulties with applying AI algorithms […]