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  • Nature Reviews Drug Discovery, Published online: 10 April 2026; doi:10.1038/d41573-026-00056-yBioconjugated oligonucleotides (BCOs) promise to expand the applicability of RNA-based medicines. Here, we present recommendations for nonclinical safety strategies in advancing BCOs into the clinic.
  • Nature Reviews Drug Discovery, Published online: 07 April 2026; doi:10.1038/d41573-026-00058-wLipid nanoparticles deliver to the pancreas
  • Nature Reviews Drug Discovery, Published online: 02 April 2026; doi:10.1038/d41573-026-00057-xDialling up the circadian clock to target ageing
  • Nature Reviews Drug Discovery, Published online: 02 April 2026; doi:10.1038/s41573-026-01407-5The oral delivery of small-molecule drugs with poor aqueous solubility represents an ongoing drug development challenge. Amorphous solid dispersions (ASDs) and lipid-based formulations (LBFs) have emerged as effective approaches to address this. This Perspective provides an overview of the design of ASDs and LBFs and examines […]
  • Nature Reviews Drug Discovery, Published online: 02 April 2026; doi:10.1038/d41573-026-00059-9FDA approves GLP-1 pill for obesity
  • Nature Reviews Drug Discovery, Published online: 30 March 2026; doi:10.1038/s41573-026-01388-5The PI3K/AKT/mTOR pathway represents an attractive drug target, but only a limited number of compounds have gained US Food and Drug Administration approval. This Perspective assesses existing class I PI3K/AKT/mTOR pathway inhibitors, highlighting lessons learned and ongoing drug development challenges. Emerging novel classes of pathway modulators, […]